Validation of heart failure events in ALLHAT participants assigned to doxazosin
نویسندگان
چکیده
منابع مشابه
Validation of Heart Failure Events in the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Participants Assigned to Doxazosin and Chlorthalidone
BACKGROUND: The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is a randomized, double-blind, active-controlled trial designed to compare the rate of coronary heart disease events in high-risk hypertensive participants initially randomized to a diuretic (chlorthalidone) versus each of three alternative antihypertensive drugs: alpha-adrenergic blocker (doxaz...
متن کاملComments on ALLHAT and doxazosin
This commentary has two purposes: to summarize the rationale, design and initial results of the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) trial; and to provide a history of the response to ALLHAT that led to a civil action and a Citizens Petition that was the basis for a public hearing by the US Food and Drug Administration, in May 2001. The author con...
متن کاملDoxazosin and congestive heart failure.
Congestive heart failure (CHF) is the most devastating cardiac sequella of long-standing hypertension. Recent data from the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) have shown the risk of CHF to be twice as high with doxazosin than with chlorthalidone. Although some questions remain regarding the diagnosis and mortality of CHF in the doxazosin arm and...
متن کاملHeart Failure Long-Term Follow-Up of Participants With Heart Failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
Linda B. Piller, MD, MPH; Sarah Baraniuk, PhD; Lara M. Simpson, PhD; William C. Cushman, MD; Barry M. Massie, MD; Paula T. Einhorn, MD, MS; Suzanne Oparil, MD; Charles E. Ford, PhD; James F. Graumlich, MD; Richard A. Dart, MD; David C. Parish, MD, MPH; Tamrat M. Retta, MD, PhD; Aloysius B. Cuyjet, MD, MPH; Syed Z. Jafri, MD; Curt D. Furberg, MD, PhD; Mohammad G. Saklayen, MBBS; Udho Thadani, MD...
متن کاملThe Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Heart Failure Validation Study: diagnosis and prognosis.
BACKGROUND ALLHAT, a randomized, double-blind, active-controlled hypertension treatment trial in 42,418 patients, reported that a thiazide-type diuretic (chlorthalidone) was superior to a calcium channel blocker (amlodipine), an angiotensin-converting enzyme inhibitor (lisinopril), and an alpha1-blocker (doxazosin) in preventing the new onset of heart failure (HF). However, questions have been ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2001
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(01)01616-8